Managing Multiple Disorders in One Body

Managing Multiple Disorders in One Body

Women with PCOS exhibit a very high degree of medical complexity, including dysfunctions of key metabolic and immune mechanisms, affecting a wide range of organ systems. Such dysfunctions can manifest as multiple disorders in one body! Identifying the root causes and common conditions that weave their way through these multiple disorders will facilitate finding a unifying remedy, and eventually a cure, for PCOS and its related conditions.

By understanding how foundational dysfunctions develop and then lead to a myriad of manifestations, we can take those crucial first steps. Conditions found at higher rates in PCOS women than in the general population includeautoimmune thyroid disease (Hashimoto’s Thyroiditis), endometriosis, uterine fibroids (leiomyomata), adenomyosis (uterine lining glands within the muscle of the uterus), and several cancers.

Are women with PCOS simply unlucky to have so many medical maladies in one body, or is there a common theme to explain this? Once you delve beneath the surface, you come to recognize that all of these conditions have similar underlying mechanisms. Uniting all of them are the following: an abnormally functioning immune system, marked by chronic inflammation with elevations of inflammatory signaling agents called inflammatory cytokines, early age exposures to environmental toxicants (chemical endocrine disruptors), nutritional deficiencies, and gut microbiome abnormalities (dysbiosis). The ultimate unifying and underlying cause for all of these maladies in PCOS women is a foundational hormonalproblem: a major dysfunction of estrogen and its receptors, including its production and metabolic degradation. Estrogen is the master hormone, essential for metabolic health,and this requires a properly regulated immune system.  Sadly, PCOS women do not have proper metabolic or immune health.

Let’s begin with a quick overview of the conditions mentioned above. Endometriosis involves a severe localized inflammation in the pelvis, with high levels of inflammatory cytokines within the intra-abdominal (peritoneal) fluid. Interestingly, most menstruating women have some uterine contents flow backwards with each menses, with fluids and tissue passing through and out the Fallopian Tubes. The body’s immune system normally dissolves and gobbles up that tissue, but in women with endometriosis, this process malfunctions, and little holes in the lining of the pelvis (the peritoneum) are created, allowing living cells from the uterine lining to implant and thrive.

This process is controlled by a system of enzymes, called Matrix Metalloproteinases (which remodel tissue) along with immune cells of the body. These cells and processes are under the control of estrogen, which in PCOS women is not functioning correctly. One type of theseimmune cells – the Mast Cell, which isalso controlled by estrogen – accumulates within the pelvis of women with endometriosis, releasingmassive quantities of inflammatory cytokines and chemokines (signaling agents which call other inflammatory white blood cells to the scene.) Thiscreates and sustainslocalized inflammation, promotinglocal estrogen production, and further stimulating growth of the ectopic endometrial cells.

In the case of uterine fibroids, malfunctioning Matrix Metalloproteinases and abnormal local production of estrogen and progesterone cause the muscle cells of the uterus to grow abnormally, creating muscle tumors – fibroids (leiomyomata). Likewise, adenomyosis involves the dysfunction of both the Matrix Metalloproteinases and of estrogen, resulting in the invasion of the endometrial (lining) cells into the muscle of the uterus.

Hashimoto’s Thyroiditis, an autoimmune disease, also involves dysfunction of the immune system, gut dysbiosis,and impaired gut permeability (leaky gut), all related to abnormal estrogen function. Lastly, cancer, the ultimate immune dysfunction, involves uncontrolled inflammation and estrogen malfunction or deficiency. Not surprisingly, the incidence of many cancers is substantially higher in women with estrogen dysfunctions – PCOS, adenomyosis, fibroids, and endometriosis – compared with the rest of the female population.

And what connects PCOS with those other conditions? What is the root cause of PCOS? We now understand that it involves chronic inflammation, gut dysbiosis, and leaky gut;and that estrogen malfunction is at the root of those problems. The cause for this estrogen malfunction involves exposures to endocrine disrupting chemicals at critical points of development – in utero, during infancy, and at puberty, in genetically susceptible women. This inflammatory state is exacerbated by continued chemical exposures and the consumption of a high fat/high sugar diet, filled with processed foods.

Despite all of this, there is substantial reason for hope. A fiber rich diet, stress control, exercise, timed eating and periodic fasting, along with the judicious use of bioidentical hormones, can ameliorate these problems. More on my PCOS protocols for health will be forthcoming in future articles.

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Eating fresh vegetables and oils help reduce risk of cardiovascular disease

Eating Fresh Vegetables and oils help reduce the risk of cardiovascular disease

A recent edition of the Journal of the American Heart Association stated that eating healthy fats lowers the risk of a cardiovascular event just as much as the use of statins does .

In most cases, I do not recommend statins, particularly for women with no history of a cardiovascular event, such as a heart attack or a stroke. There are definite downsides to the use of statins, including muscle pain, increased risks of diabetes and dementia, and rarely muscle breakdown – a condition known as rhabdomyolysis. That event can lead to renal failure and permanent kidney damage.

However, no such risks occur with eating fresh vegetables and their oils. I’d like to make a plea, however, to refrain from buying non-organic oils or oils chemically extracted. Only organic expeller-pressed oils should be eaten … or better yet … eat the whole food … like whole olives! I am a big believer in whole foods, so even oils are second-rate compared with the entire food entity, which has all the wonderful fiber and nutrients still within it!

It’s great to see a published article in a mainstream journal extol the benefits of food, and compare favorably the benefits of eating food with a pharmaceutical!! Hooray!!

Reference:Replacing Saturated Fats With Healthy Fats Lowers CVD Risk

Grey Hair Linked with Increased Heart Disease Risk in Men

Grey Hair Linked with Increased Heart Disease Risk in Men

You thought of your grey hair as a cosmetic burden to deal with, along with being an outright nuisance … and considered that to be plenty to contend with. Now it turns out that the grey is so more than “hair strand deep!” It’s now been shown, confirming what many thought already, myself included, that grey hair also meant that your insides were, at least theoretically, greying as well!

Yes – we now must add a dangerous veneer to the pain of greying hair, as it has been shown in men (ladies this most definitely should apply to you too, though your gender has yet to be studied) that it indicates a very real increased risk of cardiovascular events.

But why would this be? Why should grey strands on your noggin foretell of a disastrous heart attack or stroke? The reason for this correlation is so simple to grasp. Grey hair is a sign of oxidative stress, of an imbalance favoring free radicals! Free radicals are molecules carrying an unmatched electron,

making it exist in a state of oxidative stress – it needs an electron to balance its charge and neutralize it! It’s now an oxidant in search of an antioxidant!

In women in menopause in particular, lack of estrogen predisposes to oxidative stress and lots of free radicals. Another way to think of this is that grey hair is a sign of inflammation!! And inflammation breeds disease! If oxidative stress and free radicals exist in one place in the body, you can be safe extrapolate  that they exist everywhere! And free radicals at the level of the scalp leads to a state of inflammation and oxidative stress at the hair follicle – and hence the greying of hair!

Rather than freaking out about this, better to just swallow and take the steps needed to reduce your level of inflammation and be grateful you know the score prior to a bad event! Together we can lower your state of inflammation and lower your risk of a cardiovascular event (heart attack or stroke, or heart or kidney failure … down the line!)

With a whole foods, organic diet, filled with fiber and an array of vegetables and fruits, along with exercise, proper sleep, stress control, and detoxification – your body can be restored to a much healthier state.

And will the grey hair disappear? This has yet to be tested … so let’s see how your hair reacts!! No promises for the hair, but for sure your arteries will smile!!!


Hormonal contraceptives and hair dyes increase breast cancer risk

Hormonal Contraceptives and Hair Dyes Increase Breast Cancer Risk | University of Helsinki

I’m anti the use of Progestin embedded IUDs (intrauterine devices), and have been for a long time. Here is now another reason, based on a just published study from Finland. There are several such IUDs, which are different from the copper containing ones.

The progestin containing IUD was found to increase the risk of breast cancer by 52% in postmenopausal women. Granted this is a retrospective observational study … but it makes sense to me!! With such an IUD, you’re putting into the uterus a progesterone endocrine disruptor! Progestins (phony progesterone) block the natural and protective effects of real progesterone!! These IUDs do not contain hormones … but rather contain “anti-hormones,” toxic substances which interfere with real hormones. After all, that’s their purpose – to prevent the natural hormones of the female body from being produced and working in the ways intended for females to work!

I’m also anti oral, and otherwise delivered, chemical endocrine disruptors, known as birth control pills!! These apparently increase the risk of breast cancer by about a third. I’ve been opposed to them for some time as well. It’s especially horrifying that we place these acknowledged toxins into the bodies of young teen girls, whose bodies have not yet fully matured … including their brains!

It’s no wonder that in the USA that over a quarter of adult women use SSRI’s for depression! Of course there are other toxins entering the brains of women, and lots of other issues as well, but often women are kept, unaware of the risks, on those disgusting BCP chemicals for decades!!

I know I’m full of venum on this topic … but why on earth is no one questioning this practice and thinking about the true ramifications of such a thing? Well … at least in Finland there are some who feel as I do!!

And we won’t go over the issue of mammography right now! That was also mentioned in the study. That’s another giant topic for another day!

I know I’m an outlier on the use of chemical endocrine disruptors as contraceptives. I am universally opposed to the intentional placement of endocrine disruptors in humans.

As for the hair dye issue – at the very least, those who do dye their hair should know what the risks are. That’s the entire point of informed consent – to understand the opening and make choices intelligently, with full awareness of the options and risks!

PS: I’m on the fence now … as I do dye my hair … in this regard I’m a phony! I will immediately look into natural wash-in hair coloring. I want to be true to my pronouncements!

B’s Block Smog’s Damaging Effects

B’s Block Smog’s Damaging Effects

Air pollution is bad for you, and while most of us think in terms of coughing, wheezing, and watery eyes; the effects go way beyond this. In fact, exposure to high levels of air pollution are associated with significantly increased rates of obesity, diabetes, heart disease, asthma, dementia, and cancer. According to the World Health Organization (WHO) air pollution kills approximately 3 million people per year and is considered the greatest environmental risk to health.

While we may not know how air pollution does all its damage on the cellular and molecular levels, we are beginning to understand how it does some of its dirty work – and we’re finding ways to fight back!

A case in point is a new study just published by researchers at Columbia University’s Mailman School of Public Health. It showed that at least some of pollution’s harmful effects are the result of inflammation and oxidative stress induced by epigenetic changes made to genes involved in mitochondrial oxidative energy metabolism. (Epigenetics refers to the “turning on and off” of specific genes through the methylation process, and not the mutation, or changing, of the underlying DNA.)

Basically, they exposed ten healthy adults to three different levels of air quality for 2-hour stretches of time while also giving them sham or vitamin B supplementation. First, the subjects breathed clean air and received supplementation placebos. Next, they were exposed to “hazardous” levels of polluted air and again given supplementation placebos. Lastly, the subjects were instructed to breathe polluted air, but this time were given supplements containing three different B vitamins – folic acid, B6, and B12.

So, what did they find out? First, they confirmed that breathing polluted air increased epigenetic changes to the genes controlling mitochondrial oxidative energy metabolism. It seems that compromising mitochondrial function in this way leads to inflammation and oxidative stress. Second, they discovered that giving B vitamins was an effective way to prevent and, in fact, reverse this epigenetic damage.

What does this mean for you?

While it’s certainly true that most of us don’t live in areas with hazardously high levels of pollution, over 90% of the world’s population lives in areas where pollution exceeds the WHO’s recommended level for healthy air. We start from a base of bad quality – Southern California is no exception – and things get worse. If you get stuck in traffic on the freeway, if your office building (or your children’s’ school) backs up to a highway, if you fire up the grill this summer, or if you decide to visit cities in India, China, or Iran (just to name a few); you’re probably way over the limit of safe exposure.

What should you do?

While the best advice is to eat a healthy diet with lots of B vitamins – leafy green vegetables and beans are rich in folic acid, B6 can be found in fish, beef liver and starchy vegetables, and B12 is abundant in fish, meat, eggs and milk – sometimes this isn’t enough. To be on the safe side, especially if you have genetic issues with methylation – you may want to take a high-quality B vitamin supplement. Check with us to see which one suits your specific needs best.

Veggies and Fruits are Magical!

It’s been scientifically proven a significant number of times – vegetables and fruits are magical! They contain an array of amazing ingredients which perform amazing things for our bodies and our health.

The magical phytonutrients found in these plants can turn on and off genes, as do hormones, and do special things to help our microbiota, the trillions of bacteria within our colons and intestines, to thrive. In turn, the healthy microbiota, known collectively as the gut microbiome, can perform their magic to optimize our health.

Autoimmune disease has been reversed, cancers placed into remission, and Alzheimer’s Disease reversed, solely with lifestyle programs. The foundational ingredient of each program is and must be – nutrition. So aim to eat a dozen vegetables daily and 2-3 fruits … and see your body truly thrive!

Read more: High Fruit and Vegetable Intake Linked to Reduced Risk for CVD, Cancer, and Mortality

Helpful Hints to Ward Off the Flu: Your Flu Shot Alone Isn’t Going to be Enough to Keep You Healthy

It’s here—flu season. Scientists do their best job trying to anticipate which variants of influenza will strike and they create the flu shots for the upcoming onslaught of germs. However, they don’t know how effective it is until the first cases of flu start showing up and they can compare reality to their predictions. The statistics are in, and the vaccine has been deemed 48% effective.

Don’t despair, however, there are additional measures you can take to boost your immunity and help keep you healthy.

Take N Acetyl Cysteine (NAC) daily in the dose of 600-900 mg twice a day, and three time a day if you’re exposed! NAC has been repeatedly shown to assist in preventing flu by reducing the virus’ ability to replicate inside of your body. Additionally, NAC also reduces an inflammatory response once you are exposed. This results in less severe symptoms should you become ill.

Be sure to eat a whole foods diet with lots of vegetables! Get enough sleep! Try a diffuser with orange oil; it is quite useful at killing airborne viruses. As always, wash your hands if touching surfaces which may be contaminated. (Door handles, light switches, countertops, etc) And think positive thoughts!

If you do get sick – come see us right away for additional therapeutic modalities!!

We’ve many suggestions to help you recover faster!

Flu Vaccine 48 Percent Effective This Year, CDC Says

Bloomberg News (2/16, Cortez) reports the flu vaccine has been 48% effective so far this season, according to a report from the Centers for Disease Control and Prevention. Brendan Flannery, an epidemiologist at the CDC’s influenza division, said, “The 48 percent overall is not as good as we would like to see for flu vaccine, but the protection we see is significant.”

       Medscape (2/16, Brooks) reports CDC officials said that “elevated” influenza activity is expected to continue for several more weeks in some parts of the US. Lenee Blanton of the CDC’s Influenza Division said in the report that influenza activity began to pick up in mid-December and has been “elevated” since February 4.